Calculate 2012 CAD2 Clinical and CCS PTP for obstructive CAD — calculate_cad2_2012_clinical_ccs

This function returns a patient's pre-test probability (PTP) of obstructive coronary artery disease (CAD) based on the 2012 CAD Consortium 2 (CAD2) clinical and coronary calcium score (CCS) model. Obstructive coronary artery disease was defined as $\geq$50% diameter stenosis in at least one vessel found on catheter based coronary angiography.

Usage

calculate_cad2_2012_clinical_ccs_ptp(
  age,
  sex,
  chest_pain_type,
  have_diabetes,
  have_hypertension,
  have_dyslipidemia,
  have_smoking_history,
  coronary_calcium_score,
  label_sex_male = c("male"),
  label_sex_female = c("female"),
  label_sex_unknown = c(NA, NaN),
  label_cpt_nonanginal = c("nonanginal"),
  label_cpt_atypical = c("atypical"),
  label_cpt_typical = c("typical"),
  label_cpt_unknown = c(NA, NaN),
  label_have_diabetes_no = c("no"),
  label_have_diabetes_yes = c("yes"),
  label_have_diabetes_unknown = c(NA, NaN),
  label_have_hypertension_no = c("no"),
  label_have_hypertension_yes = c("yes"),
  label_have_hypertension_unknown = c(NA, NaN),
  label_have_dyslipidemia_no = c("no"),
  label_have_dyslipidemia_yes = c("yes"),
  label_have_dyslipidemia_unknown = c(NA, NaN),
  label_have_smoking_history_no = c("no"),
  label_have_smoking_history_yes = c("yes"),
  label_have_smoking_history_unknown = c(NA, NaN)
)

Arguments

age: Input numeric value to indicate the age of the patient in years.
sex: The value of variable in the parameters label_sex_male,
label_sex_female and label_sex_unknown.
chest_pain_type: The value of variable in the parameters,
label_cpt_nonanginal, label_cpt_atypical,
label_cpt_typical and label_cpt_unknown.
have_diabetes: The value of variable in the parameters label_have_diabetes_no,
label_have_diabetes_yes and label_have_diabetes_unknown.
have_hypertension: The value of variable in the parameters label_have_hypertension_no,
label_have_hypertension_yes, and label_have_hypertension_unknown.
have_dyslipidemia: The value of variable in the parameters label_have_dyslipidemia_no,
label_have_dyslipidemia_yes and label_have_dyslipidemia_unknown.
have_smoking_history: The value of variable in the parameters label_have_smoking_history_no,
label_have_smoking_history_yes,
and label_have_smoking_history_unknown.
coronary_calcium_score: Input non-negative numeric to indicate the total coronary calcium score of the patient.
label_sex_male: Label(s) for definition(s) of male sex. Default: c("male")
label_sex_female: Label(s) for definition(s) of female sex. Default: c("female")
label_sex_unknown: Label(s) for definition(s) of missing sex. Default: c(NA, NaN)
label_cpt_nonanginal: Label(s) for patient having nonanginal or non-specific chest pain.
Default: c("nonanginal")
label_cpt_atypical: Label(s) for patient having atypical chest pain. Default: c("atypical")
label_cpt_typical: Label(s) for patient having typical chest pain. Default: c("typical")
label_cpt_unknown: Label(s) for patient having unknown chest pain type symptoms. Default: c(NA, NaN)
label_have_diabetes_no: Label(s) for patient with no diabetes. Default: c("no")
label_have_diabetes_yes: Label(s) for patient having diabetes. Default: c("yes")
label_have_diabetes_unknown: Label(s) for patient having unknown diabetes. Default: c(NA, NaN)
label_have_hypertension_no: Label(s) for patient with no hypertension. Default: c("no")
label_have_hypertension_yes: Label(s) for patient having hypertension. Default: c("yes")
label_have_hypertension_unknown: Label(s) for patient having unknown hypertension. Default: c(NA, NaN)
label_have_dyslipidemia_no: Label(s) for patient with no dyslipidemia. Default: c("no")
label_have_dyslipidemia_yes: Label(s) for patient having dyslipidemia. Default: c("yes")
label_have_dyslipidemia_unknown: Label(s) for patient having unknown dyslipidemia. Default: c(NA, NaN)
label_have_smoking_history_no: Label(s) for patient with no smoking history (current or past). Default: c("no")
label_have_smoking_history_yes: Label(s) for patient having smoking history (current or past). Default: c("yes")
label_have_smoking_history_unknown: Label(s) for patient having unknown smoking history (current or past). Default: c(NA, NaN)

Value

A numeric value representing the patient's PTP for obstructive CAD based on the 2012 CAD Consortium 2 (CAD2) clinical and coronary calcium score (CCS) model.

Details

The predictive model is based on patients from 18 hospitals in Europe and the United States.

A web-based calculator is accessible.

Model formula used is from Appendix Table 4.

It is of the form $$\frac{1}{(1 + e^{-F(x)})}$$ where $F(x)$ equals $$ \begin{array}{l} -5.975\quad+ \\\\ (0.011 * age)\quad+ \\\\ (0.786 * sex\_is\_male)\quad+ \\\\ (0.718 * have\_atypical\_chest\_pain)\quad+ \\\\ (2.024 * have\_typical\_chest\_pain)\quad+ \\\\ (0.658 * have\_diabetes)\quad+ \\\\ (0.235 * have\_hypertension)\quad+ \\\\ (0.185 * have\_dyslipidemia)\quad+ \\\\ (0.207 * have\_smoking\_history)\quad+ \\\\ (0.577 * ln(CACS + 1))\quad+ \\\\ (-0.780 * have\_diabetes * have\_typical\_chest\_pain) \end{array} $$

Examples

# 40 year old female with typical chest pain,
# diabetes but no hypertension, dyslipidemia,
# a non-smoker and a coronary calcium score of 0
calculate_cad2_2012_clinical_ccs_ptp(
    age = 40,
    sex = "female",
    chest_pain_type = "typical",
    have_diabetes = "yes",
    have_hypertension = "no",
    have_dyslipidemia = "no",
    have_smoking_history = "no",
    coronary_calcium_score = 0

)
#> [1] 0.02575585