Calculate 2018 Chen MFS PTP (formula version) for obstructive CAD — calculate_chen_2018_mfs_formula

This function returns a patient's pre-test probability (PTP) of obstructive coronary artery disease (CAD) based on the 2018 Chen et. al. modified Framingham scoring (MFS) model. Obstructive CAD was defined as ($\geq$50% stenosis by diameter in at least one major coronary vessel based on coronary angiography)

Usage

calculate_chen_2018_mfs_formula_ptp(
  age,
  sex,
  have_hypertension,
  tc_mg_dl,
  hdl_mg_dl,
  lvef_percent,
  hsCRP_mg_dl,
  have_anemia,
  label_sex_male = c("male"),
  label_sex_female = c("female"),
  label_sex_unknown = c(NA, NaN),
  label_have_hypertension_no = c("no"),
  label_have_hypertension_yes = c("yes"),
  label_have_hypertension_unknown = c(NA, NaN),
  label_have_anemia_no = c("no"),
  label_have_anemia_yes = c("yes"),
  label_have_anemia_unknown = c(NA, NaN)
)

Arguments

age: Input numeric value to indicate the age of the patient in years.
sex: The value of variable in the parameters label_sex_male,
label_sex_female and label_sex_unknown.
have_hypertension: The value of variable in the parameters label_have_hypertension_no,
label_have_hypertension_yes, and label_have_hypertension_unknown.
tc_mg_dl: Input positive numeric value to indicate the patient's total cholesterol in $mg/dL$.
hdl_mg_dl: Input positive numeric value to indicate the patient's high-density lipoprotein (HDL) in $mg/dL$.
lvef_percent: Input positive numeric value to indicate the patient's Left Ventricular Ejection Fraction (LVEF) in $\%$
hsCRP_mg_dl: Input positive numeric value to indicate the patient's high-sensitivity C reactive protein (hs-CRP) in $mg/dL$.
have_anemia: The value of variable in the parameters label_have_anemia_no,
label_have_anemia_yes, and
label_have_anemia_unknown.
label_sex_male: Label(s) for definition(s) of male sex. Default: c("male")
label_sex_female: Label(s) for definition(s) of female sex. Default: c("female")
label_sex_unknown: Label(s) for definition(s) of missing sex. Default: c(NA, NaN)
label_have_hypertension_no: Label(s) for patient with no hypertension. Default: c("no")
label_have_hypertension_yes: Label(s) for patient having hypertension. Default: c("yes")
label_have_hypertension_unknown: Label(s) for patient having unknown hypertension. Default: c(NA, NaN)
label_have_anemia_no: Label(s) for patient without anemia. Default: c("no")
label_have_anemia_yes: Label(s) for patient with anemia. The paper uses baseline hematocrit value <39% for men and <36% for women. Default: c("yes")
label_have_anemia_unknown: Label(s) for patient with no information if they have anemia or not. Default: c(NA, NaN)

Value

A numeric value representing the patient's PTP for obstructive CAD based on the 2018 modified Framingham scoring (MFS) model.

Details

The predictive model is based on patients from a prospective observational study Predictive Value of Contrast Volume to Creatinine Clearance Ratio (PRECOMIN) conducted primarily at Guangdong General Hospital.

Model formula is of the form $$\frac{1}{(1 + e^{-F(x)})}$$ where $F(x)$ equals $$ \begin{array}{l} -0.0468\quad+ \\\\ (0.0204 * age)\quad+ \\\\ (1.0961 * sex\_is\_male)\quad+ \\\\ (0.5444 * have\_hypertension)\quad+ \\\\ (0.0055 * total\_cholesterol\_mg\_dl)\quad+ \\\\ (-0.0257 * hdl\_mg\_dl)\quad+ \\\\ (-0.022 * LVEF\_\%)\quad+ \\\\ (0.5677 * have\_anemia)\quad+ \\\\ (0.0254 * hs-CRP\_mg\_dl) \end{array} $$

Examples

# 40 year old female with no hypertension
# and anemia. She has a
# total cholesterol level of 150 mg/dL
# high-density lipoprotein cholesterol level of 70 mg/dL and
# high-sensitivity C reactive protein level of 1 mg/dL with
# a left Ventricular Ejection Fraction reading of 60%
calculate_chen_2018_mfs_formula_ptp(
    age = 40,
    sex = "female",
    have_hypertension = "no",
    tc_mg_dl = 150,
    hdl_mg_dl = 70,
    lvef_percent = 60,
    hsCRP_mg_dl = 1,
    have_anemia = "no"
)
#> [1] 0.182515