Calculate 2025 Rasmussen CACS-CLCCTA PTP model for obstructive CAD — calculate_rasmussen_2025_cacs_cl_ccta

This function returns a patient's pre-test probability (PTP) of obstructive coronary artery disease based on 2025 Rasmussen et. al. Coronary Artery Calcium Score-Weighted Clinical Likelihood CCTA (RF-CL_CCTA) model. Obstructive CAD was defined as a stenosis causing $\geq$ 50% diameter stenosis on coronary CTA.

Usage

calculate_rasmussen_2025_cacs_cl_ccta_ptp(
  age,
  sex,
  chest_pain_type,
  have_dyspnoea,
  have_family_history,
  have_smoking_history,
  have_dyslipidemia,
  have_hypertension,
  have_diabetes,
  coronary_calcium_score,
  allow_na_symptom_score = TRUE,
  max_na_num_of_rf = 0,
  label_sex_male = c("male"),
  label_sex_female = c("female"),
  label_sex_unknown = c(NA, NaN),
  label_have_dyspnoea_no = c("no"),
  label_have_dyspnoea_yes = c("yes"),
  label_have_dyspnoea_unknown = c(NA, NaN),
  label_cpt_no_chest_pain = c("no chest pain"),
  label_cpt_nonanginal = c("nonanginal"),
  label_cpt_atypical = c("atypical"),
  label_cpt_typical = c("typical"),
  label_cpt_unknown = c(NA, NaN),
  label_have_family_history_no = c("no"),
  label_have_family_history_yes = c("yes"),
  label_have_family_history_unknown = c(NA, NaN),
  label_have_smoking_history_no = c("no"),
  label_have_smoking_history_yes = c("yes"),
  label_have_smoking_history_unknown = c(NA, NaN),
  label_have_dyslipidemia_no = c("no"),
  label_have_dyslipidemia_yes = c("yes"),
  label_have_dyslipidemia_unknown = c(NA, NaN),
  label_have_hypertension_no = c("no"),
  label_have_hypertension_yes = c("yes"),
  label_have_hypertension_unknown = c(NA, NaN),
  label_have_diabetes_no = c("no"),
  label_have_diabetes_yes = c("yes"),
  label_have_diabetes_unknown = c(NA, NaN)
)

Arguments

age: Input numeric value to indicate the age of the patient in years.
sex: The value of variable in the parameters label_sex_male,
label_sex_female and label_sex_unknown.
chest_pain_type: The value of variable in the parameters label_cpt_no_chest_pain,
label_cpt_nonanginal,
label_cpt_atypical,
label_cpt_typical,
and label_cpt_unknown.
have_dyspnoea: The value of variable in the parameters label_have_dyspnoea_no,
label_have_dyspnoea_yes and label_have_dyspnoea_unknown.
have_family_history: The value of variable in the parameters label_have_family_history_no,
label_have_family_history_yes
and label_have_family_history_unknown.
have_smoking_history: The value of variable in the parameters label_have_smoking_history_no,
label_have_smoking_history_yes,
and label_have_smoking_history_unknown.
have_dyslipidemia: The value of variable in the parameters label_have_dyslipidemia_no,
label_have_dyslipidemia_yes and label_have_dyslipidemia_unknown.
have_hypertension: The value of variable in the parameters label_have_hypertension_no,
label_have_hypertension_yes, and label_have_hypertension_unknown.
have_diabetes: The value of variable in the parameters label_have_diabetes_no,
label_have_diabetes_yes and label_have_diabetes_unknown.
coronary_calcium_score: Input non-negative numeric to indicate the total coronary calcium score of the patient.
allow_na_symptom_score: A logical evaluating to TRUE or FALSE
indicating whether we can allow chest_pain_type
or have_dyspnoea to be NA when calculating the score.
max_na_num_of_rf: Input integer 0 to 5 to indicate the maximum number of missing risk factors to tolerate before outputting an NA. Default: 0
label_sex_male: Label(s) for definition(s) of male sex. Default: c("male")
label_sex_female: Label(s) for definition(s) of female sex. Default: c("female")
label_sex_unknown: Label(s) for definition(s) of missing sex. Default: c(NA, NaN)
label_have_dyspnoea_no: Label(s) for patient having no dyspnoea symptoms. Default: c("no")
label_have_dyspnoea_yes: Label(s) for patient having dyspnoea symptoms. Default: c("yes")
label_have_dyspnoea_unknown: Label(s) for patient having unknown dyspnoea symptoms. Default: c(NA, NaN)
label_cpt_no_chest_pain: Label(s) for patient having no chest pain. Default: c("no chest pain")
label_cpt_nonanginal: Label(s) for patient having nonanginal or non-specific chest pain.
Default: c("nonanginal")
label_cpt_atypical: Label(s) for patient having atypical chest pain. Default: c("atypical")
label_cpt_typical: Label(s) for patient having typical chest pain. Default: c("typical")
label_cpt_unknown: Label(s) for patient having unknown chest pain type symptoms. Default: c(NA, NaN)
label_have_family_history_no: Label(s) for patient with no family history of CAD. Default: c("no")
label_have_family_history_yes: Label(s) for patient having family history of CAD. Default: c("yes")
label_have_family_history_unknown: Label(s) for patient having unknown family history of CAD. Default: c(NA, NaN)
label_have_smoking_history_no: Label(s) for patient with no smoking history (current or past). Default: c("no")
label_have_smoking_history_yes: Label(s) for patient having smoking history (current or past). Default: c("yes")
label_have_smoking_history_unknown: Label(s) for patient having unknown smoking history (current or past). Default: c(NA, NaN)
label_have_dyslipidemia_no: Label(s) for patient with no dyslipidemia. Default: c("no")
label_have_dyslipidemia_yes: Label(s) for patient having dyslipidemia. Default: c("yes")
label_have_dyslipidemia_unknown: Label(s) for patient having unknown dyslipidemia. Default: c(NA, NaN)
label_have_hypertension_no: Label(s) for patient with no hypertension. Default: c("no")
label_have_hypertension_yes: Label(s) for patient having hypertension. Default: c("yes")
label_have_hypertension_unknown: Label(s) for patient having unknown hypertension. Default: c(NA, NaN)
label_have_diabetes_no: Label(s) for patient with no diabetes. Default: c("no")
label_have_diabetes_yes: Label(s) for patient having diabetes. Default: c("yes")
label_have_diabetes_unknown: Label(s) for patient having unknown diabetes. Default: c(NA, NaN)

Value

A numeric value representing the patient's PTP for obstructive CAD based on the 2025 Rasmussen et. al. Coronary Artery Calcium Score-Weighted Clinical Likelihood CCTA (RF-CL_CCTA) model.

Model formula used is from Development Table 2.

It is of the form $$\frac{1}{(1 + e^{-F(x)})}$$ where $F(x)$ equals $$ \begin{array}{l} 0.014533\quad+ \\\\ (0.27093 * rf\_ptp)\quad+ \\\\ (0.047056 * cacs\_1\_to\_9)\quad+ \\\\ (0.11890 * cacs\_10\_to\_99)\quad+ \\\\ (0.34417 * cacs\_100\_to\_399)\quad+ \\\\ (0.5881 * cacs\_400\_to\_999)\quad+ \\\\ (0.73892 * cacs\_1000\_or\_more)\quad+ \\\\ (0.054423 * rf\_ptp * cacs\_1\_to\_9)\quad+ \\\\ (0.14347 * rf\_ptp * cacs\_10\_to\_99)\quad+ \\\\ (0.18439 * rf\_ptp * cacs\_100\_to\_399)\quad+ \\\\ (0.085774 * rf\_ptp * cacs\_400\_to\_999)\quad+ \\\\ (-0.081776 * rf\_ptp * cacs\_1000\_or\_more) \end{array} $$

Examples

# 40 year old Male with nonanginal chest pain and coronary calcium score of 0
calculate_rasmussen_2025_cacs_cl_ccta_ptp(
    age = 40,
    sex = "male",
    chest_pain_type = "no chest pain",
    have_dyspnoea = "no",
    have_family_history = "no",
    have_smoking_history = "no",
    have_dyslipidemia = "no",
    have_hypertension = "no",
    have_diabetes = "no",
    coronary_calcium_score = 0,
    allow_na_symptom_score = TRUE,
    max_na_num_of_rf = 0
)
#> [1] 0.02729926