Calculate 2019 Reeh Basic PTP for obstructive CAD

This function returns a patient's pre-test probability (PTP) of obstructive coronary artery disease (CAD) based on the 2019 Reeh et. al. basic model. Obstructive CAD was defined from invasive angiography as >70% stenosis of any epicardial vessel or 50–70% stenosis with a fractional flow reserve <0.8 or any lesion that was revascularized.

Usage

calculate_reeh_2019_basic_ptp(
  age,
  sex,
  symptom_type,
  label_sex_male = c("male"),
  label_sex_female = c("female"),
  label_sex_unknown = c(NA, NaN),
  label_symptom_type_typical = c("typical"),
  label_symptom_type_atypical = c("atypical"),
  label_symptom_type_nonanginal = c("nonanginal"),
  label_symptom_type_dyspnoea = c("dyspnoea"),
  label_symptom_type_unknown = c(NA, NaN)
)

Arguments

age

Input numeric value to indicate the age of the patient in years.

sex

The value of variable in the parameters label_sex_male, label_sex_female and label_sex_unknown.

symptom_type

Input characters (typical, atypical, nonanginal, dyspnoea) to indicate the symptom characteristics of the patient.

• typical stands for the patient having typical chest pain.

• atypical stands for the patient having atypical chest pain.

• nonanginal stands for the patient having nonanginal or non-specific chest pain.

• dyspnoea stands for the patient having dyspnoea.

label_sex_male

Label(s) for definition(s) of male sex. Default: c("male")

label_sex_female

Label(s) for definition(s) of female sex. Default: c("female")

label_sex_unknown

Label(s) for definition(s) of missing sex. Default: c(NA, NaN)

label_symptom_type_typical

Label(s) for patient having typical chest pain. Default: c("typical")

label_symptom_type_atypical

Label(s) for patient having atypical chest pain. Default: c("atypical")

label_symptom_type_nonanginal

Label(s) for patient having nonanginal or non-specific chest pain.
Default: c("nonanginal")

label_symptom_type_dyspnoea

Label(s) for patient having dyspnoea. Default: c("dyspnoea")

label_symptom_type_unknown

Label(s) for patient having unknown symptoms. Default: c(NA, NaN)

Value

A numeric value representing the patient's PTP for obstructive CAD based on the 2019 Reeh et. al. basic model.

Details

The predictive model is based on 3903 patients free of CAD and heart failure and suspected of angina, who were referred to a single, large, urban university hospital for assessment in 2012–15.

Model formula used is from Table 3.

It is of the form $$\frac{1}{(1 + e^{-F(x)})}$$ where \(F(x)\) equals $$ \begin{array}{l} -7.6348\quad+ \\\\ (1.4067 * sex\_is\_male)\quad+ \\\\ (0.4820 * (age/10))\quad+ \\\\ (2.8779 * have\_typical\_chest\_pain)\quad+ \\\\ (1.8690 * have\_atypical\_chest\_pain)\quad+ \\\\ (0.7916 * have\_dyspnoea) \end{array} $$

Examples

# 40 year old female with typical chest pain
calculate_reeh_2019_basic_ptp(
    age = 40,
    sex = "female",
    symptom_type = "typical"
)
#> [1] 0.05578231