Calculate 2020 Winther CACS-CL PTP model for obstructive CAD

This function returns a patient's pre-test probability (PTP) of obstructive coronary artery disease based on 2020 Winther et. al. Coronary Artery Calcium Score-Weighted Clinical Likelihood (CACS-CL) model.

Usage

calculate_winther_2020_cacs_cl_ptp(
  age,
  sex,
  chest_pain_type,
  have_dyspnoea,
  have_family_history,
  have_smoking_history,
  have_dyslipidemia,
  have_hypertension,
  have_diabetes,
  coronary_calcium_score,
  allow_na_symptom_score = TRUE,
  max_na_num_of_rf = 0
)

Arguments

age

Input numeric value to indicate the age of the patient.

sex

Input characters (female, male) to indicate the sex of the patient.

• female

• male

chest_pain_type

Input characters (no chest pain, typical, atypical, nonanginal) to indicate the chest pain characteristics of the patient.

• no chest pain stands for the patient having no chest pain.

• typical stands for the patient having typical chest pain.

• atypical stands for the patient having atypical chest pain.

• nonanginal stands for the patient having nonanginal or non-specific chest pain.

have_dyspnoea

Input characters (no, yes) to indicate if the patient only has dyspnoea symptoms.

• no stands for not having dyspnoea symptoms.

• yes stands for having dyspnoea symptoms.

have_family_history

Input characters (no, yes) to indicate if the patient only has a family history of CAD.

• no stands for not having a family history of CAD.

• yes stands for having a family history of CAD.

have_smoking_history

Input characters (no, yes) to indicate if the patient only has a smoking history (current or past smoker).

• no stands for not having a smoking history (non-smoker).

• yes stands for having a smoking history (current or past smoker).

have_dyslipidemia

Input characters (no, yes) to indicate if the patient only has dyslipidemia.

• no stands for not having dyslipidemia.

• yes stands for having a dyslipidemia.

have_hypertension

Input characters (no, yes) to indicate if the patient only has hypertension.

• no stands for not having hypertension.

• yes stands for having a hypertension.

have_diabetes

Input characters (no, yes) to indicate if the patient only has diabetes.

• no stands for not having diabetes.

• yes stands for having diabetes.

coronary_calcium_score

Input non-negative numeric to indicate the total coronary calcium score of the patient.

allow_na_symptom_score

A logical evaluating to TRUE or FALSE indicating whether we can allow chest_pain_type or have_dyspnoea to be NA when calculating the score

max_na_num_of_rf

Input integer 0 to 5 to indicate the maximum number of missing risk factors to tolerate before outputting an NA. Default: 0

Value

A numeric value representing the patient's PTP for obstructive CAD based on the 2020 Winther et. al. Coronary Artery Calcium Score-Weighted Clinical Likelihood (CACS-CL) model.

Details

The predictive model is based on > 40000 symptomatic patients from 2008 to 2017 from 13 hospitals in Western Denmark. These patients are registered under the Western Denmark Heart Registry.

Examples

# 40 year old Male with nonanginal chest pain and coronary calcium score of 0
calculate_winther_2020_cacs_cl_ptp(
    age = 40,
    sex = "male",
    chest_pain_type = "no chest pain",
    have_dyspnoea = "no",
    have_family_history = "no",
    have_smoking_history = "no",
    have_dyslipidemia = "no",
    have_hypertension = "no",
    have_diabetes = "no",
    coronary_calcium_score = 0,
    allow_na_symptom_score = TRUE,
    max_na_num_of_rf = 0
)
#> [1] 0.004159686